Levodopa Challenge Test Predicts STN-DBS Outcomes in Various Parkinson’s Disease Motor Subtypes: A More Accurate Judgment

Table 2

Comparison of baseline and postoperative indices among the three subtype groups in the validation set.

	Total ()	TD ()	AR ()	MX ()	ANOVA	TD vs. AR	TD vs. MX	AR vs. MX
Sex (male/female)	157/147	43/37	32/35	82/75
Reach MICID in UPDRS-III ()	145 (47.7%)	35 (43.8%)	45 (67.1%)	65 (41.4%)
Reach MOCID in PDQ-39 ()	76 (51.7%)	41 (41.7%)	32 (47.8%)	82 (52.2%)
Age at surgery (years)					0.178
Age at onset (years)					0.003	<0.001	0.178	0.232
DD (years)					0.235
Duration of MF (years)					<0.001	<0.001	0.234	0.015
H-Y on					0.012	0.123	0.228	0.022
H-Y off					0.172	0.243	0.919	0.843
UPDRS-III on					0.202
UPDRS-III off					0.043	0.381	1.000	0.126
LR for UPDRS-III (%)					0.371
LR for tremor score (%)					0.207
LR for akinetic-rigid score (%)					<0.001	<0.001	<0.001	0.945
LEDD					0.015	0.023	0.847	0.030
PDQ-39					<0.001	<0.001	0.026	0.365
HAMD					0.333
HAMA					0.013	0.019	0.433	0.636
Post UPDRS-III on					0.003	0.002	0.936	0.012
Post UPDRS-III off					0.002	<0.001	0.623	0.008
Post PDQ-39					<0.001	<0.001	0.023	0.078

TD: tremor-dominated patients; AR: akinetic-rigid-dominated patients; MX: mixed patients; MICID: minimal clinically important difference; MOCID: moderate clinically important difference; DD: duration of diagnosis; MF: motor fluctuation; H-Y: Hoehn-Yahr stage; UPDRS: Unified Parkinson’s Disease Rating Scale; LR: levodopa response; LEDD: levodopa equivalent doses; PDQ-39: Parkinson’s Disease Questionnaire-39; HAMD: Hamilton depression scale; HAMA: Hamilton anxiety scale; Post: postoperative; Post UPDRS-III on: on-stimulation/on-medicine; Post UPDRS-III off: on-stimulation/off-medicine. value. Significant comparisons are highlighted in bold.