Microglia: A Potential Drug Target for Traumatic Axonal Injury

Figure 1

Microglia and TAI: traumatic brain injury will activate microglia rapidly, and microglia will transform from the resting state to the activated state. In the acute phase, activated microglia include proinflammatory and anti-inflammatory phenotypes which will play a role in axonal damage and repair, respectively. While in the chronic phase, activated microglia are mainly proinflammatory and will take part in the long-term process of axonal injury after TBI.