Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Cluster location</td><td class="align_center" colspan="3">Peak (MNI)</td><td class="align_center" rowspan="2">Number of voxels</td><td class="align_center" rowspan="2"><svg height="9.01194pt" id="M57" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -8.96212 8.41168 9.01194" width="8.41168pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z"></path></g></svg> value</td></tr><tr class="thead"><td 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transform="matrix(.013,0,0,-0.013,93.488,0)"><path d="M319 325C317 349 306 409 297 431C277 440 250 449 209 449C117 449 57 389 57 319C57 243 122 209 182 182C232 159 261 135 261 91C261 48 227 21 190 21C130 21 85 79 68 145L41 140C41 104 51 36 58 22C75 7 121 -12 172 -12C252 -12 337 35 337 126C337 195 286 231 210 262C166 281 126 304 126 348C126 388 152 417 191 417C240 417 274 378 294 318L319 325Z"></path></g></svg></span></td><td class="align_left"></td><td class="align_left"></td><td class="align_left"></td><td class="align_left"></td><td class="align_left"></td></tr><tr><td class="align_left">LIFG, pars triangularis</td><td class="align_center">-48</td><td class="align_center">33</td><td class="align_center">18</td><td class="align_center">35</td><td class="align_center">4.1653</td></tr><tr><td class="align_left">Left PCu/SOG</td><td class="align_center">-9</td><td class="align_center">-81</td><td class="align_center">42</td><td class="align_center">53</td><td class="align_center">5.3697</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>BD: bipolar disorder; GFC: global-brain functional connectivity; LIFG: left inferior frontal gyrus; PCu: precuneus; SOG: superior occipital gyrus; MNI: Montreal Neurological Institute.<br/></div></td></tr></table>

<div>Significant differences in GFC values between groups.</div>

Neural Plasticity

tab2

Table 2

Table 2: Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder 

Table 2 | Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder 