Comparative Transcriptome Profiling Reveals Changes of microRNAs Response to Exercise in Rats with Neuropathic Pain

Figure 5

Expression profile changes in microRNAs (miRNAs) in the dorsal root ganglion (DRG). (a) Volcano plots of RNA-sequencing data showing differentially expressed miRNAs between the chronic constrictive injury (CCI) and sham-operated groups. (b) Volcano plot showing differentially expressed miRNAs between the CCI and CCI-exercised groups. Magenta dots represent genes with significantly upregulated expression, blue dots represent genes with significantly downregulated expression, and grey dots represent genes with no significant difference. (c) Overlap of differentially expressed miRNAs between the two comparisons shown as a Venn diagram. (d) Heatmap showing the relative expression levels of differentially expressed miRNAs among the three groups. Upregulated and downregulated genes are colored red and blue, respectively ( animals per group).

(a)

(b)

(c)

(d)