Comparative Transcriptome Profiling Reveals Changes of microRNAs Response to Exercise in Rats with Neuropathic Pain

Figure 6

Expression profile changes in mRNA in the dorsal root ganglion (DRG). (a) Volcano plot indicating upregulated and downregulated differentially expressed mRNAs between the chronic constrictive injury (CCI) and sham-operated groups. (b) Volcano plot indicating upregulated and downregulated differentially expressed mRNAs between the CCI and CCI-exercised groups. Magenta dots represent genes with significantly upregulated expression, blue dots represent genes with significantly downregulated expression, and grey dots represent genes with no significant difference. (c) Overlap of differentially expressed mRNAs between the two comparisons shown as a Venn diagram. (d) Heatmap showing the relative expression levels of differentially expressed mRNAs among the three groups. Upregulated and downregulated genes are colored red and blue, respectively ( animals per group).

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