The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration

Figure 1

Preconditioning injury paradigm. (a) The DRGs are pseudounipolar neurons, dividing their axons into peripheral and central branches. The peripheral branches aggregate into the sciatic nerve to innervate sensory targets, and the central branches enter into the dorsal column and relay sensory information to the brain stem. (b) The central branch of DRG failed to regenerate after spinal cord injury. (c) A prior injury of the sciatic nerve could enhance the regrowth capacity of DRG to elicit regeneration of axons in the central nerve system following a subsequent spinal injury.

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(b)

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