The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration

Figure 2

Signal transduction of peripheral nerve preconditioning injury regulates the RAG expression. Retrograded injury signaling after sciatic nerve injury includes calcium wave, a sensor of axon injury DLK, and axoplasmic importins. The injury signaling elicit genetic program to express RAGs and TFs responsible for enhancing axon growth. RAGs: regeneration-associated genes; TFs: transcription factors; CDKN1B: cyclin-dependent kinase inhibitor 1B; TIMP3: tissue inhibitor of metalloproteinase 3.