The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration

Figure 3

Interaction between neurons and nonneurons after PNS preconditioning injury. The preconditioning sciatic nerve injury increased the number of macrophages and inflammatory mediators and drives macrophage activation toward DRG. The interactions amplify and maintain RAGs and TF expression to enhance axon regeneration. SGC: satellite glial cells; CCL2:C-C motif chemokine ligand 2; CCR2: C-C motif chemokine receptor 2; NOXs: NADPH oxidase 2 complexes.