Abnormal Default-Mode Network Homogeneity in Melancholic and Nonmelancholic Major Depressive Disorder at Rest

Table 2

Significant DMN NH differences across groups.

Cluster location	Peak (MNI)			Number of voxels	value
	Melancholic vs. healthy controls
Left inferior temporal gyrus	-48	-12	-27	32	-3.3543
Right middle temporal gyrus	45	3	-27	49	-3.9893
Left middle temporal gyrus	-63	-39	0	28	-2.9141
Left PCC/precuneus	-6	-48	15	30	-2.8359
Right superior medial frontal gyrus	15	60	3	22	2.6930
Left superior medial frontal gyrus	-9	57	9	23	3.1756
Right anterior cingulate cortex	12	42	12	22	2.4894
Right angular gyrus	60	-57	39	27	2.3859
Right PCC/precuneus	18	-51	33	48	3.6568
Nonmelancholic vs. healthy controls
Right middle temporal gyrus	51	-18	-21	54	-3.1047
Left superior medial frontal gyrus	-6	60	33	36	-2.6479
Right superior medial frontal gyrus	6	57	36	28	-3.5704
Right PCC/precuneus	18	-54	33	41	3.7047
Right angular gyrus	54	-57	33	21	2.7685
Melancholic vs. nonmelancholic
Left inferior temporal gyrus	-54	-15	-30	83	-3.6810
Left superior medial frontal gyrus	-9	57	6	38	3.1369
Right superior medial frontal gyrus	9	57	42	70	2.6833

DMN: default-mode network; NH: network homogeneity; MNI: Montreal Neurological Institute; PCC: posterior cingulate cortex.