The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model

Figure 4

Schematic illustration of the relationship between the Wnt/β-catenin pathway and neuropathic pain. The relationship between the Wnt/β-catenin pathway and neuropathic pain in the CCD model was possibly that CCD surgery caused activation of the Wnt/β-catenin pathway; then, active β-catenin accumulated in the cytoplasm and translocated into the nucleus. Subsequently, the transcription of the target genes TNF-α and IL-18 increased, leading to neuropathic pain finally, while the Wnt/β-catenin inhibitor XAV939 can suppress this process, relieving CCD-induced neuropathic pain.