Impaired Limb Functional Outcome of Peripheral Nerve Regeneration Is Marked by Incomplete Recovery of Paw Muscle Atrophy and Brain Functional Connectivity in a Rat Forearm Nerve Repair Model

Figure 4

Brain functional reorganization analysis of the primary motor cortex (M1) after nerve repair. We performed a seed-based whole-brain functional connectivity (FC) analysis of the contralateral primary motor cortex (M1) between the nerve repair and the nerve injury groups (repair-injury). The rat contralateral M1 cortex (left) demonstrated an extensive FC reorganization (marked in red) with bilateral sensory cortex (S1) as well as right dorsal striatum (dS) at week 8.