Investigation of Neuron Latency Modulated by Bilateral Inferior Collicular Interactions Using Whole-Cell Patch Clamp Recording in Brain Slices

Figure 6

The influence of contralateral IC activation on subthreshold depolarization duration on the recording side. (a) A typical neuron exhibiting a shortened latency (#201607411002-E-5-1). (b–d) Three typical neurons exhibiting prolonged latencies (#20160613003-E-5-1, #20160903003-E-5-1, and #20160616002-E-5-1). 1–3 depict the subthreshold depolarization duration in control, contralateral activated, and recovery conditions, respectively. 4 is the neural response when the injected depolarized current is 0 pA, and synaptic input is induced in the contralateral IC. (e, f) Show the comparison of latency-shortened neurons and latency-prolonged neurons under MT+30 in control, contralateral IC activated, and recovery conditions. ; ; (paired -tests). (g) Shows the correlation analysis of variation in latency and duration of the subthreshold depolarization. is the correlation coefficient, and the solid line indicates the regression curve. is the significance level.