Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders

Figure 1

Functions of K2P channels in the peripheral nervous system. Left: TREK-1 and TRAAK are enriched in nodes of Ranvier on myelinated afferent nerves. The channels rapidly regenerate action potentials, allowing fast action potential conduction along the nerve. Right: K2P channels are expressed in neurons of the dorsal root ganglion and trigeminal ganglion. They extrude K⁺ and hyperpolarize the membrane of neurons at rest, decreasing their excitability.