Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders

Figure 2

Roles of K2P channels in the central nervous system. K2P channels regulate neuronal excitability and contribute to many normal and disease processes, including sleep, epilepsy, ischemia, and depression. In glia, K2P channels maintain glial membrane potential and are involved in astrocytic passive conductance and glutamate release, microglial surveillance, myelin generation by oligodendrocytes, and K⁺ homeostasis.