Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway

Figure 2

Nesting activity was altered by exposure to cuprizone and partially rescued by quetiapine and SZASD. (a) Representative images of nesting activity of mice in the control, CPZ, CPZ+L(SZASD), CPZ+M(SZASD), CPZ+H(SZASD), and CPZ+QTP groups. (b) Histogram of nesting scores in mice among the six different groups. Values are expressed as median (interquartile range) (, , model group vs. control group; ^#, ^##, drug groups vs. model group). Legend: CPZ+L(SZASD): 8.65 g·kg^-1·d^-1; CPZ+M(SZASD): 17.29 g·kg^-1·d^-1; CPZ+H(SZASD): 25.94 g·kg^-1·d^-1; CPZ+QTP: 10 mg·kg^-1·d^-1.

(a)

(b)