Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway

Figure 3

Locomotor activity and PPI deficits due to exposure to cuprizone rescued by quetiapine and SZASD. (a) Representative movement traces of mice in the control, CPZ+NS, CPZ+L(SZASD), CPZ+M(SZASD), CPZ+H(SZASD), and CPZ+QTP groups. (b) (i) Comparison of total locomotor activity (total movement distance in 30 min) of mice among groups. (ii) Comparison of center zone movement distance in 30 min of mice among groups. (c) Comparison of (i) PPI at 75 dB with a 30 ms interval and (ii) PPI at 75 dB with a 100 ms interval among groups. Values are expressed as (Standard Error of Mean) (-14, , model group vs. control group; ^#, ^##, drug groups vs. model group). Legend: CPZ+L(SZASD): 8.65 g·kg^-1·d^-1; CPZ+M(SZASD): 17.29 g·kg^-1·d^-1; CPZ+H(SZASD): 25.94 g·kg^-1·d^-1; CPZ+QTP: 10 mg·kg^-1·d^-1.

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