Electroacupuncture Ameliorates Neuroinflammation-Mediated Cognitive Deficits through Inhibition of NLRP3 in Presenilin1/2 Conditional Double Knockout Mice

Figure 6

MCC950 does not further increase the effect of EA on ameliorated hyperphosphorylated tau and impaired NMDA receptors in the hippocampus of PS cDKO mice. (a) Representative Western blot of NR1, NR2A, NR2B, p-tau (Ser396), and p-tau (Se404) in the hippocampus. (b)–(f) Quantification of NR1, NR2A, NR2B, p-tau (Ser396), and p-tau (Ser404) in the hippocampus according to the respective levels of β-actin or total tau ( mice for each group). The values were expressed as relative changes to the respective WT mice, which was set to 1. Data are the , , vs WT mice. ^#, ^## vs cDKO mice.

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