Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy

<div>Effect of rHDGF antibody on expressions of HDGF, p-Akt/Akt, PI3K, substance P, and TrkB in the L3/L5 spinal cord dorsal horn of RTX-rats. After the rats were divided into three groups, neuropathy was induced by intraperitoneally administration of a single dose of RTX (50 <i>μ</i>g/kg). In the RTX+rHDGF antibody group, 100 <i>μ</i>g/kg rHDGF antibody was administered and applied 24 hours before RTX injection. The control group received no rHDGF antibody pretreatment and no RTX injection. At 3 or 7 days after RTX injection and/or pretreated with rHDGF antibody, L3-L5 spinal cord dorsal horn were harvested and protein expressions were measured through western blot analysis. (a) Representative Western blot results. 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Neural Plasticity

fig5

Figure 5

Figure 5: Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy 