Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses

Figure 2

Schematic diagram of the operational process (a). RNA-seq analysis of glucagon-like peptide 1 receptor agonism exenatide induced responses after spinal nerve ligation. Unbiased principal component analysis (b) and heat map (c) of mRNA transcriptome in the spinal ipsilateral dorsal horn. The network of genes (d) and the Kyoto Encyclopedia of Genes and Genomes pathways (e) differentially enriched in the SNL and sham groups. The network of genes (f) and signaling (g) differentially enriched in the exenatide and sham groups (). Gene number: number of target genes in each pathway. Rich factor: the ratio of the number of target genes divided by the number of all the genes in each pathway.

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