Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses

<div>Expression of glucagon-like peptide 1 receptor/IL-10/<i>β</i>-endorphin/<i>μ</i>-opioid receptor (MOR) in the ipsilateral side. IL-10 and <i>β</i>-endorphin mRNA (a), MOR agonist DAMGO (b), and <i>β</i>-endorphin (c) induced outward currents, excitability (d), and inhibitory effect of <i>β</i>-endorphin on the sham (e) and SNL (f) groups. Rats were induced with neuropathy by the ligation of spinal nerves. Neurons were obtained from the lamina II spinal dorsal horn neurons. 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Neural Plasticity

fig4

Figure 4

Figure 4: Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses 