Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia

Figure 3

SVR results suggest that high VMHC levels at baseline in the superior/middle MPFC predict therapeutic response in the patient group. (a–c, left) SVR parameter selection results (3D visualization). and were the logarithm of parameters and . (a–c, right) A positive correlation between predicted and actual RRs of the PANSS total scores (, ), positive symptom subscale scores (, ), and negative symptom subscale scores (, ) of individual patients after eight weeks of olanzapine treatment. VMHC = voxel-mirrored homotopic connectivity; SVR = support vector regression; PANSS = positive and negative syndrome scale; MPFC = medial prefrontal cortex; RR = reduction ratio.

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