Research Article
Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia
Table 2
Alterations of VMHC across patients (at baseline, after 8 weeks of treatment) and controls.
| | Cluster location | Peak coordinate | Cluster (voxel) | value | | | |
| | Patients at baseline vs. controls | | | | | | | Orbital IFG/STG | ±51 | 21 | -12 | 184 | -3.6668 | | Fusiform gyrus/cerebellum VI | ±39 | -42 | -30 | 392 | -3.9664 | | STG | ±54 | -21 | 0 | 118 | -3.7539 | | MTG/angular gyrus | ±45 | -51 | 18 | 200 | -3.3522 | | Opercular IFG | ±63 | 12 | 9 | 84 | -3.4363 | | Superior MPFC | ±27 | 66 | 15 | 70 | -3.4842 | | Middle MPFC | ±30 | 39 | 39 | 64 | -3.6280 | | Precentral gyrus | ±33 | -15 | 36 | 66 | -3.8381 | | Superior/middle MPFC | ±21 | 15 | 54 | 92 | -3.2115 | | Precentral gyrus/postcentral gyrus | ±36 | -27 | 66 | 60 | -2.8298 | | Precuneus | ±0 | -75 | 48 | 200 | -3.0148 | | Median cingulum gyrus | ±0 | -18 | 36 | 118 | 3.1627 | | Medial orbital FG | ±0 | 39 | -12 | 66 | -2.5950 | | Patients after 8 weeks vs. at baseline | | | | | | | Superior/middle MPFC | ±24 | 12 | 51 | 62 | 5.6466 |
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VMHC = voxel-mirrored homotopic connectivity; IFG = inferior frontal gyrus; STG = superior temporal gyrus; MPFC = medial prefrontal cortex; MTG = middle temporal gyrus; FG = frontal gyrus.
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