Deletion of Clusterin Protects Cochlear Hair Cells against Hair Cell Aging and Ototoxicity

Figure 6

Clu deficiency protects hearing ability and inhibits sensory cell death induced by the coadministration of kanamycin and furosemide. (a) Assessment of auditory dysfunction in WT and Clu^−/− mice treated with furosemide plus kanamycin. . (b) Quantification of OHCs and IHCs in WT and Clu^−/− mice after treatment with furosemide plus kanamycin. Data are presented as the . , . . (c) Representative confocal microscopy images from WT and Clu^−/− mice after treatment with furosemide plus kanamycin.

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