[Retracted] Molecular Basis of GABA Hypofunction in Adolescent Schizophrenia-Like Animals

Figure 5

Protein network analysis of GABA neurotransmission. (a) Pearson correlation analysis of the expression of significant proteins involved in GABA neurotransmission. The number inside the circle represents the value. (b) Network of proteins involved in GABA neurotransmission. Blue: downregulated proteins. Grey: proteins whose expression were not changed in this study by MS analysis. Circle size represents the value of the adjusted value. The larger size indicated the smaller value. The value of blue circles was below 0.05; otherwise, they were above 0.05. The thickness of lines represents the combined score of edges. (c) Western blot validation of the GAD65 expression, of each group, . (d) Western blot validation of the GAD67 expression. of each group, . Data were represented as . . Student’s -test. (e) Schema depicting the contribution of downregulated proteins in GABA dysfunction. GAD65 and SYNPR are responsible for GABA synthesis and release, respectively. GAT3 reuptakes GABA in the synaptic cleft. DBI is the GAGB_A receptor. SN1 transports GABA-derived glutamine to GABAergic neurons for GABA replenishment.

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