Research Article

Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice

Table 1

Correlations between groups with regard to performance in the MWM and hippocampal synaptic proteins.

Cognitive phasesAgesGroupsSynaptic proteins
ArcSyt1

Learning phase
 Swimming latency3 monthsCON0.530 (0.177)0.289 (0.488)
LPS0.815 (0.014)0.797 (0.018)
LPS-E0.679 (0.064)0.768 (0.026)
15 monthsCON0.653 (0.079)0.891 (0.003)
LPS0.851 (0.007)0.755 (0.03)
LPS-E0.848 (0.008)0.945 (0.000)
 Swimming distance3 monthsCON-0.176 (0.667)-0.238 (0.571)
LPS0.907 (0.002)0.905 (0.002)
LPS-E-0.267 (0.552)-0.217 (0.606)
15 monthsCON0.609 (0.109)0.797 (0.018)
LPS0.951 (0.000)0.959 (0.000)
LPS-E0.817 (0.013)0.962 (0.000)

Memory phase
 Time percentage in target quadrant3 monthsCON-0.140 (0.740)0.086 (0.840)
LPS-0.712 (0.048)-0.685 (0.061)
LPS-E-0.720 (0.044)-0.557 (0.152)
15 monthsCON-0.849 (0.008)-0.849 (0.008)
LPS-0.940 (0.001)-0.934 (0.001)
LPS-E-0.921 (0.001)-0.935 (0.001)
 Distance percentage in target quadrant3 monthsCON-0.461 (0.250)0.566 (0.143)
LPS-0.929 (0.001)-0.889 (0.003)
LPS-E-0.744 (0.034)-0.673 (0.068)
15 monthsCON-0.611 (0.107)-0.836 (0.01)
LPS-0.942 (0.000)-0.829 (0.011)
LPS-E-0.744 (0.034)-0.781 (0.022)

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