Research Article
Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice
Table 1
Correlations between groups with regard to performance in the MWM and hippocampal synaptic proteins.
| Cognitive phases | Ages | Groups | Synaptic proteins | Arc | Syt1 | | |
| Learning phase | | | | | Swimming latency | 3 months | CON | 0.530 (0.177) | 0.289 (0.488) | LPS | 0.815 (0.014) | 0.797 (0.018) | LPS-E | 0.679 (0.064) | 0.768 (0.026) | 15 months | CON | 0.653 (0.079) | 0.891 (0.003) | LPS | 0.851 (0.007) | 0.755 (0.03) | LPS-E | 0.848 (0.008) | 0.945 (0.000) | Swimming distance | 3 months | CON | -0.176 (0.667) | -0.238 (0.571) | LPS | 0.907 (0.002) | 0.905 (0.002) | LPS-E | -0.267 (0.552) | -0.217 (0.606) | 15 months | CON | 0.609 (0.109) | 0.797 (0.018) | LPS | 0.951 (0.000) | 0.959 (0.000) | LPS-E | 0.817 (0.013) | 0.962 (0.000) |
| Memory phase | | | | | Time percentage in target quadrant | 3 months | CON | -0.140 (0.740) | 0.086 (0.840) | LPS | -0.712 (0.048) | -0.685 (0.061) | LPS-E | -0.720 (0.044) | -0.557 (0.152) | 15 months | CON | -0.849 (0.008) | -0.849 (0.008) | LPS | -0.940 (0.001) | -0.934 (0.001) | LPS-E | -0.921 (0.001) | -0.935 (0.001) | Distance percentage in target quadrant | 3 months | CON | -0.461 (0.250) | 0.566 (0.143) | LPS | -0.929 (0.001) | -0.889 (0.003) | LPS-E | -0.744 (0.034) | -0.673 (0.068) | 15 months | CON | -0.611 (0.107) | -0.836 (0.01) | LPS | -0.942 (0.000) | -0.829 (0.011) | LPS-E | -0.744 (0.034) | -0.781 (0.022) |
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