Research Article
Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice
Table 2
Correlations between groups with regard to performance in the MWM and hippocampal mRNAs.
| | Cognitive phases | Ages | Groups | Arc mRNA | Syt1 mRNA | | CA1 | CA3 | DG | CA1 | CA3 | DG | | | | | | |
| | Learning phase | | | | | | | | | | Swimming latency | 3 months | CON | 0.347 (0.399) | 0.488 (0.220) | -0.278 (0.505) | 0.363 (0.377) | 0.175 (0.679) | 0.405 (0.319) | | LPS | 0.873 (0.005) | 0.878 (0.004) | 0.09 (0.833) | 0.891 (0.003) | 0.930 (0.001) | 0.069 (0.870) | | LPS-E | 0.177 (0.674) | 0.394 (0.334) | -0.053 (0.901) | 0.805 (0.016) | 0.639 (0.088) | 0.197 (0.640) | | 15 months | CON | 0.250 (0.550) | 0.887 (0.003) | -0.115 (0.785) | 0.909 (0.002) | 0.858 (0.006) | -0.480 (0.228) | | LPS | 0.496 (0.211) | 0.813 (0.014) | -0.594 (0.120) | 0.900 (0.002) | 0.915 (0.001) | 0.860 (0.006) | | LPS-E | 0.727 (0.041) | 0.672 (0.068) | -0.658 (0.076) | 0.497 (0.211) | 0.821 (0.012) | 0.721 (0.044) | | Swimming distance | 3 months | CON | 0.214 (0.611) | 0.532 (0.175) | 0.458 (0.254) | -0.200 (0.635) | -0.125 (0.769) | 0.588 (0.125) | | LPS | 0.877 (0.004) | 0.848 (0.008) | 0.089 (0.834) | 0.877 (0.004) | 0.736 (0.037) | -0.378 (0.356) | | LPS-E | 0.128 (0.763) | -0.687 (0.060) | 0.309 (0.457) | -0.232 (0.580) | -0.538 (0.169) | 0.307 (0.459) | | 15 months | CON | 0.037 (0.930) | 0.884 (0.004) | 0.260 (0.534) | 0.913 (0.002) | 0.860 (0.006) | -0.614 (0.106) | | LPS | 0.488 (0.265) | 0.834 (0.010) | -0.558 (0.150) | 0.917 (0.001) | 0.858 (0.006) | 0.821 (0.011) | | LPS-E | 0.734 (0.038) | 0.564 (0.145) | -0.528 (0.179) | 0.669 (0.070) | 0.809 (0.015) | 0.801 (0.017) |
| | Memory phase | | | | | | | | | | Time percentage in target quadrant | 3 months | CON | 0.566 (0.143) | -0.07 (0.869) | 0.378 (0.356) | 0.418 (0.303) | 0.233 (0.579) | 0.082 (0.848) | | LPS | -0.756 (0.03) | -0.797 (0.018) | 0.185 (0.660) | -0.810 (0.015) | -0.816 (0.014) | 0.321 (0.438) | | LPS-E | 0.037 (0.931) | -0.124 (0.769) | -0.228 (0.490) | -0.600 (0.116) | -0.855 (0.007) | 0.007 (0.987) | | 15 months | CON | -0.394 (0.335) | -0.818 (0.013) | 0.125 (0.767) | -0.899 (0.002) | -0.798 (0.018) | 0.337 (0.414) | | LPS | -0.351 (0.393) | -0.933 (0.001) | 0.577 (0.135) | -0.842 (0.009) | -0.781 (0.022) | -0.714 (0.047) | | LPS-E | -0.866 (0.005) | -0.679 (0.064) | 0.603 (0.114) | -0.601 (0.115) | -0.789 (0.020) | -0.669 (0.070) | | Distance percentage in target quadrant | 3 months | CON | 0.142 (0.738) | 0.040 (0.924) | 0.159 (0.706) | -0.01 (0.980) | 0.372 (0.365) | -0.249 (0.552) | | LPS | -0.935 (0.001) | -0.947 (0.000) | -0.197 (0.640) | -0.921 (0.001) | -0.930 (0.001) | -0.203 (0.629) | | LPS-E | 0.304 (0.464) | -0.447 (0.267) | -0.071 (0.867) | -0.788 (0.020) | -0.780 (0.022) | -0.035 (0.935) | | 15 months | CON | -0.003 (0.994) | -0.888 (0.003) | -0.142 (0.738) | -0.902 (0.002) | -0.803 (0.016) | 0.694 (0.056) | | LPS | -0.679 (0.064) | -0.733 (0.038) | 0.352 (0.392) | -0.748 (0.033) | -0.786 (0.021) | -0.880 (0.004) | | LPS-E | -0.753 (0.031) | -0.468 (0.242) | 0.276 (0.508) | -0.228 (0.587) | -0.818 (0.014) | -0.451 (0.262) |
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