p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice

Figure 5

p38 MAPK knockdown reduced the expression of c-caspase-3 in hippocampus CA1 pyramidal cells. (a) Representative images of western blotting in WT and p38 ^KI/+ mice after ischemia/reperfusion surgery at 9 weeks of age. (b) Quantification of c-caspase-3 activation expression (cleaved-caspase-3/caspase-3) in the hippocampus, mice in the sham group, the WT & I/R group, and the p38^KI/+ & I/R group. per group; , sham group vs. I/R group; , p38^KI/+ & I/R group vs. I/R group. by one-way ANOVA.

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