Research Article
p38 MAPK Endogenous Inhibition Improves Neurological Deficits in Global Cerebral Ischemia/Reperfusion Mice
Figure 6
p38 MAPK knockdown rescues apoptosis and DNA damage after cerebral ischemia and reperfusion. (a) TUNEL staining photomicrographs at 3 days after cerebral ischemia/reperfusion in the WT & I/R group. (b) TUNEL staining photomicrographs at 3 d after cerebral ischemia and reperfusion in the p38KI/+ & I/R group. (c) TUNEL staining photomicrographs in the sham group by TUNEL staining. (d) Apoptotic TUNEL-positive cells (%) of TUNEL staining in hippocampal CA1; the p38KI/+ & I/R group was lower than the WT & I/R group, respectively ( per group; , sham group vs. I/R group; , p38KI/+ & I/R vs. I/R group.). The slice thickness is 16 μm under a ×400 microscope image (red brown indicates Klenow- or TUNEL-positive cells by black arrows; blue depicts nucleus; scale bars 20 mm). by one-way ANOVA.
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