Research Article

Low-Frequency rTMS over Contralesional M1 Increases Ipsilesional Cortical Excitability and Motor Function with Decreased Interhemispheric Asymmetry in Subacute Stroke: A Randomized Controlled Study

Table 1

Demographic and clinical characteristics of participants.

VariableExperimental ()Control () value

Demographic and clinical characteristics
Age (years)67.3 (5.8)65.1 (3.1)0.216
Time since stroke (weeks)13.6 (6.1)15.1 (7.0)0.582
Gender (female : male) ()5 : 75 : 71.000
Paretic limb (right : left) ()4 : 86 : 60.408
Type of stroke (infarct : hemorrhage) ()12 : 011 : 10.307
Paretic hand (dominant : nondominant) ()4 : 86 : 60.408
Site of lesion (subcortical only : cortical involvement, ) ()12 : 09 : 30.217
Resting motor threshold (paretic hand) (% stimulator output)85.5 (14.5)80.6 (12.7)0.320
Resting motor threshold (nonparetic hand) (% stimulator output)77.3 (8.3)72.6 (12.3)0.524
Primary outcome measures
Fugl-Meyer motor assessment46.7 (13.9)48.8 (14.9)0.549
MEP amplitude (paretic hand) (μV)258.3 (278.0)600.1 (374.6)0.002
MEP amplitude (nonparetic hand) (μV)316.8 (229.4)693.5 (380.3)0.035
IHA-0.39 (0.67)0.06 (0.39)0.155
Secondary outcome measures
Grip strength (kg)12.6 (11.3)13.8 (10.8)0.792
Action Research Arm Test36.5 (17.8)41.1 (17.8)0.332
Nine-hole peg test (median (IQR)) (s)351 (553)328 (565)0.734
Box and block test (number of blocks)17.2 (20.5)33.8 (18.7)0.049
Reaction time (ms)985.8 (439.9)654.2 (285.5)0.068
Stroke Impact Scale59.0 (13.3)65.7 (10.3)0.141

Note: mean (SD) presented unless indicated otherwise; MEP: motor-evoked potential; IHA: interhemispheric asymmetry; IQR: interquartile range. Significant between-group difference ().