Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome

Figure 2

Localization of synaptic SK2 in hippocampal CA1 region of female AS and WT mice. (a) Representative images of CA1 pyramidal neurons stained with anti-SK2 (red) and -PSD95 (green) antibodies. Middle panels are enlarged images of boxed areas in top panels and bottom panels are enlarged images of boxed areas in middle panels. Arrowheads indicate clearly colocalized puncta. Top panels,  μm. Middle panels,  μm. Bottom panels,  μm. (b) Quantitative analysis of the intensity and number of SK2- and PSD95-immunoreactive puncta and SK2 and PSD95 colocalization in hippocampal CA1 region. mice per group (unpaired t-test, , , ).

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