Inhibition of Cerebral Ischemia/Reperfusion Injury by MSCs-Derived Small Extracellular Vesicles in Rodent Models: A Systematic Review and Meta-Analysis

Table 2

Risk of bias of the included studies.

ID

Study

①

②

③

④

⑤

⑥

⑦

⑧

⑨

⑩

Score

1

B. Feng [38]

U

Y

U

Y

Y

U

U

Y

Y

Y

6

2

C. Cheng [36]

U

U

U

U

U

U

U

Y

Y

Y

3

3

G. Li [32]

U

U

U

Y

U

U

U

U

Y

Y

3

4

H. Hao [28]

Y

Y

U

U

U

U

U

Y

Y

U

4

5

H. Yang [45]

U

Y

U

Y

U

U

U

Y

Y

Y

5

6

H. Yu [49]

U

Y

U

Y

U

U

U

U

Y

Y

4

7

K. Chen [39]

U

Y

U

Y

U

U

U

Y

Y

Y

5

8

K. Hou [29]

U

Y

U

Y

U

U

U

Y

Y

Y

5

9

K. R. Nalamolu [27]

U

Y

U

Y

U

U

U

Y

Y

U

4

10

L. Xu [33]

U

U

U

Y

U

U

U

Y

Y

Y

4

11

M. Han [40]

U

Y

U

Y

U

U

U

U

Y

Y

4

12

Q. Pan [43]

U

Y

U

Y

U

U

U

U

Y

Y

4

13

W. Wang [44]

U

Y

U

Y

U

U

U

Y

Y

Y

5

14

X. Huang [26]

U

Y

U

Y

U

U

U

U

Y

Y

4

15

X. Li [34]

U

Y

U

U

U

U

U

Y

Y

Y

4

16

X. Li [42]

U

Y

U

Y

U

U

Y

U

Y

Y

5

17

X. Liu [35]

U

Y

U

Y

U

U

U

U

Y

Y

4

18

Y. AN [48]

U

Y

U

Y

U

U

U

Y

Y

Y

5

19

Y. Ye [46]

Y

Y

Y

Y

Y

U

Y

Y

Y

Y

9

20

Y. Zhao [30]

U

Y

U

Y

U

U

U

U

Y

Y

4

21

Y. Zhao [47]

U

Y

U

Y

U

U

U

Y

Y

Y

5

22

Z. Hou [41]

U

Y

U

Y

U

U

U

U

Y

Y

4

23

Z. Pan [31]

U

Y

U

Y

U

U

U

Y

Y

Y

5

24

Z. Zhang [37]

U

U

U

Y

U

U

Y

U

Y

Y

4

①: Was the allocation sequence adequately generated and applied; ②: were the groups similar at baseline or were they adjusted for confounders in the analysis; ③: was the allocation adequately concealed; ④: were the animals randomly housed during the experiment; ⑤: were the caregivers and/or investigators blinded from knowledge which intervention each animal received during the experiment; ⑥: were animals selected at random for outcome assessment; ⑦: was the outcome assessor blinded; ⑧: were incomplete outcome data adequately addressed; ⑨: are reports of the study free of selective outcome reporting; ⑩: was the study apparently free of other problems that could result in high risk of bias. Y: yes; N: no; U: uncertain.