ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells

Figure 2

H₂O₂ induces aggravated oxidative damage to cochlear by suppression of SIRT3. (a) Representative images of ribbon synapses (red) and HCs (green) in the middle region of cochlear explants in 0, 0.5, 0.75, and 1 mM groups pretreated with 3-TYP. The white arrows indicate OHC damaged areas. Yellow arrows indicate IHC damaged areas. (b) Comparison of ribbon synapse at each concentration between matched and 3-TYP groups. (c) Comparison of OHC survival at each concentration between matched and 3-TYP groups. (d) Comparison of IHC survival at each concentration between matched and 3-TYP groups. Data are shown as ( in each group). , , and .  μm.

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