ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells

<div>H<sub>2</sub>O<sub>2</sub> induces ROS generation, which is enhanced by 3-TYP. (a) Confocal images of MitoSOX staining (red) in the 0, 0.5, 0.75, and 1 mM groups pretreated with or without 3-TYP. The white arrows indicate OHC damaged areas. Yellow arrows indicate IHC damaged areas. (b) Relative level of fluorescence intensity in each group. 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Neural Plasticity

fig3

Figure 3

Figure 3: ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells 