Review Article

Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review

Table 2

The overview of the 16 included studies.

Publication yearFirst authorFunding organizationfMRI examination timeStudy typeStroke typeAphasia durationType of AG patientNumber of acupuncture groupType of CG patientNumber of control groupTreatment durationHandednessOutcome index

2021Binlong Zhang [42]Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBefore and after treatmentObservationalIschemic1-6 monthsPoststroke Broca aphasia36Healthy volunteer24Not depictedRight handedWAB, BDAE
2021Defu Zhao [58]Natural Science of Guizhou ProvinceBefore and after treatmentRCTNot depicted16 days-5 monthsPoststroke aphasia48Poststroke aphasia481 monthNot depictedCRRCAE, MoCA, clinic efficacy
2021Xiaolin Li [45]National Research Projects for Public Welfare IndustriesBefore and after treatmentRCTIschemic14 days-6 monthsPoststroke Broca aphasia21Poststroke Broca aphasia208 weeksRight handedCRRCAE
2019Binlong Zhang [60]Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBefore and after treatmentObservationalIschemic1-6 monthsPoststroke aphasia31Healthy volunteer261 monthRight handedWAB, BDAE
2019Yukang Xiao [59]Affiliated Hospital of Hubei University of MedicineBefore and after treatmentRCTNot depicted0-6 weeksPoststroke aphasia50Poststroke aphasia5030 daysNot depictedCRRCAE, CFCP, SAQOL-39
2018Mingge Yang [52]Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese MedicineBefore and after treatmentRCTNot limitedWithin 2 yearsPoststroke Broca aphasia15Poststroke Broca aphasia154 weeksRight handedCRRCAE, BDAE, SF-36
2018Shun Li [61]Guangdong Provincial Science and technology ProjectBefore and after treatmentRCTIschemic14 days-3 monthsPoststroke Broca aphasia11Poststroke Broca aphasia121 monthRight handedCRRCAE, CFCP, ADL
2017Jingling Chang [53]Doctoral Fund of the Ministry of Education of ChinaInstantObservationalIschemic or HE14 days-2 yearsPoststroke Broca aphasia22Poststroke Broca aphasia21Instant acupunctureRight handedCRRCAE, BDAE
2016Aiqin Wang [62]Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBefore and after treatmentObservationalIschemic in cortical1-6 monthsPoststroke Broca aphasia10Healthy volunteer1030 daysRight handedWAB, BDAE
2016Binlong Zhang [56]Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBefore and after treatmentObservational11 ischemic and 1 hemorrhage in basal gangliaā€”Poststroke aphasia12Healthy volunteer1230 daysRight handedWAB, BDAE
2016Jinying Liu [63]Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBefore and after treatmentObservationalIS32-90 daysPoststroke Broca aphasia10Healthy volunteer1030 daysRight handedBDAE, WAB
2016Yuping Yuan [57]Xinjiang Medical UniversityBefore and after treatmentRCTIschemic in the left hemisphereā€”Poststroke aphasia20Poststroke aphasia204 weeksRight handedABU, NIHSS
2013Jinhuan Liu [64]Research Project of Hubei Provincial Department of EducationBefore and after treatmentRCTNot limited7-10 daysPoststroke aphasia10Poststroke aphasia1030 daysRight handedABC, clinic efficacy
2012Ni Li [65]Affiliated Hospital of Hubei University of Traditional Chinese MedicineBefore and after treatmentRCTIschemic0-6 monthsPoststroke Broca aphasia20Poststroke Broca aphasia204 weeksRight handedABC, NIHSS, ADL
2011Geng Li [54]Hong Kong Jockey Club Charities TrustInstantObservational6 ischemic and 1 hemorrhage in the left hemisphereMore than 6 monthsPoststroke aphasia7Healthy volunteer14Instant acupunctureRight handedWAB
2010Anson C.M. Chau [55]The study was approved by the institutional review board of the University of Hong Kong/Hospital Authority Hong Kong West ClusterBefore and after treatmentObservationalIschemic in the left hemispherePoststroke aphasia5Poststroke aphasia224 daysRight handedCAB

ABC: Aphasia Battery of Chinese; ABU: Aphasia Battery of Uighur; ADL: activities of daily living; AG: acupuncture group; BDAE: Boston Diagnostic Aphasia Exam; CAB: Cantonese Aphasia Battery; CFCP: Chinese Functional Communication Profile; CG: control group; CRRCAE: China Rehabilitation Research Center Aphasia Examination; MoCA: Montreal Cognitive Assessment; NIHSS: National Institutes of Health Stroke Scale; RCT: randomized controlled trial; SAQOL-39: Stroke-Aphasia Quality of Life-39; SF-36: Medical Outcome Study Short Form-36; WAB: Western Aphasia Battery.