Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway

Figure 5

AS-IV and calpain-1 knockout inhibit hypoxia-induced activation of the calpain-1/HIF-1α/caspase-3 pathway in mouse hippocampal neurons. (a–c) Western blotting was used to detect calpain-1 and HIF-1α protein expression (; calpain-1, ; HIF-1α, ). (d–f) After YC-1 was introduced, the protein expression of calpain-1 and caspase-3 was detected by Western blotting (; calpain-1, ; caspase-3, ). Data are presented as the . compared with the HBD group, ^## compared with the ASIV 60 mg/kg group.

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