Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance

Figure 1

The effects of chronic restraint stress on behavior. (a) Schedule of behavioral experiments. Beginning at day 0 and concluding on day 10, each animal was assigned to the RSD group. From day 11 to day 15, the mice were subjected to SIT, EPM, and SPT each day, and brain samples were collected at day 16. (b) Definitions of the social interaction zone and the social avoidance zone (grey and black rectangles, respectively). (c) Horizontal scatterplot depicting the distribution of interaction ratios for control. The durations in the social interaction zone (d) and social avoidance zone (e) in wild-type (WT) mice with or without RSD. (f) The duration of the open arms in the elevated plus maze test as an index for anxiety of wild-type mice. (g) The proportion of the sucrose intake as an index for depression of wild-type mice after RSD. RSD: repeated social defeat; SIT: social interaction test; Con: control mice; Sus: susceptible mice; Re: resilient mice; SI: social interaction; SA: social avoidance. One-way ANOVA followed by Turkey’s post hoc test was applied to all comparisons (Con, ; Sus, ; Res, ). Data are presented as the .

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