Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Figure 1

Characteristics of the miR-23-27-24 cluster knockout mice. Wild-type (WT) and miR-23-27-24 cluster knockout (KO). (a) Appearance of the 10-week-old WT and KO mice. (b) Expression levels of the miR-23-27-24 cluster miRNAs in the spinal cord of 10-week-old WT and KO mice, per genotype. (c) Expression levels of the miR-23-27-24 cluster miRNAs in the brain of 10-week-old WT and KO mice, per genotype. In the KO mice, the expression of all miRNAs was significantly lower in both the spinal cord and brain. Significant difference compared to wild-type mice, .

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