Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Figure 10

Expression of candidate targets of miR-23-27-24 cluster. Wild-type (WT) and miR-23-27-24 cluster knockout (KO). (a) Representative western blots depicting phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and lamin B1 levels in the spinal cord of 10-week-old mice. (b) PTEN expression was not significantly different between WT and KO mice, per genotype. (c) Lamin B1 expression was not significantly different between WT and KO mice, per genotype. (d) Proteome analysis of the spinal cord tissue from 10-week-old mice, per genotype. Leucine-zipper-like transcription regulator 1 (LZTR1) was strongly expressed in KO mice compared to WT mice.

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