Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Figure 11

Expression of LZTR1 and its downstream signaling factors. Wild-type (WT) and miR-23-27-24 cluster knockout (KO), per genotype. (a) Representative western blots of LZTR1, R-RAS, Erk1/2, phospho-Erk1/2 (p-Erk1/2), Akt, phospho-Akt1/2 (p-Akt), and GAPDH. (b) The expression of LZTR1 was significantly higher in KO mice than in WT mice, . (c) The expression of R-RAS was significantly lower in KO mice than in WT mice, . (d) The ratio of p-Erk1/2 expression to Erk1/2 expression was significantly lower in KO mice than in WT mice, . (e) The ratio of p-Akt expression to Akt expression was not significantly different between KO and WT mice.

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