Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Figure 4

Luxol Fast Blue staining of the brain and spinal cord sections. Wild-type (WT) and miR-23-27-24 cluster knockout (KO), per group. (a) Representative images of Luxol Fast Blue stained transverse sections of the thoracic spinal cord and coronal sections of the corpus callosum in WT and KO mice at 4 weeks, 10 weeks, and 12 months of age. Scale bars: 200 μm. (b) The ratio of the white matter area to the total area of the spinal cord (ratio of white matter). Compared to 4-week-old. Compared to 10-week-old. ^†Comparison between WT and KO mice, . (c) The thickness of the corpus callosum (CC). Compared to 4-week-old. Compared to 10-week-old. ^†Comparison between WT and KO mice, .

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