chronic alcohol consumpt cac can lead korsakoff syndrom memori defici attribut diencephali damag medial tempor cortic relat dysfunct the etiolog remain unclear most anim model involv thiaminedefici diet associ pyrithiamin treatment here present mous model cacinduc demonstr cacgener retriev memori deficit work episod memori task togeth reduct fear reactiv result from damag mammillari bodi experiment lesion nonalcohol mice produc same memori emot impair drug have anxiogeniclik properti counteract impair produc cac lesion suggest essenti compon brain network under emot process which would critic import retriev process involv work episod memori task failur maintain emot arous due damag can main factor cacinduc memori deficit overal our anim model fit well general neuropsycholog anatom impair observ

Daniel Béracochéa

Interaction Between Emotion and Memory: Importance of Mammillary Bodies Damage in a Mouse Model of the Alcoholic Korsakoff Syndrome

Georges Chapouthier

Pathological Changes in Memory Processing

benzodiazepin well establish inhibitori modul memori process this effect especi promin when appli befor acquisit phase memori task this minireview concentr putat subtyp select acquisitionimpair action benzodiazepin name recent genet studi standard behavior test employ subtypeselect ligand point predomin involv two subtyp benzodiazepin bind site memori modul explicit memori learn seem affect through gaba receptor contain 1 5 subunit wherea effect procedur memori can main mediat 1 subunit the pervad involv 1 subunit memori modul all unexpect becaus subunit major subtyp present 60 all gaba receptor other hand role 5 subunit main express hippocampus modul distinct form memori give promis select pharmacolog cope certain memori deficit state

Miroslav M. Savic

Dragan I. Obradovic

Nenad D. Ugrešic

Dubravko R. Bokonjic

Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes

noveltyseek harmavoid person trait influenc nogo gng learn human animal studi have also indic link between respons novelti spatial discrimin learn present studi test hypothesi learn rate gng task correl behavior respons göttingen minipig novelti group 12 minipig mix gender respons novelti measur number contact novel object total durat explor novel object these paramet were correl individu learn rate gng task the number session reach criterion gng task correl signific number contact novel object 070 003 durat object explor 029 041 thus pig low behavior respons novelti learn gng task faster than did pig strong behavior respons novelti indic tendenc approach novel object hypothes critic factor relat differ emot reactiv rather than differ motiv explor conclus addit cognit abil temperament factor like influenc learn individu pig

Nanna Marie Lind

Anette Moustgaard

Response to Novelty Correlates with Learning Rate in a Go/No-Go Task in Göttingen Minipigs

most brain insulin come from pancrea taken brain what appear receptorbas carrier type 2 diabet anim model associ insulin resist show reduc insulin brain uptak content recent data point chang insulin receptor cascad obesityrel insulin resist suggest brain insulin receptor also becom less sensit insulin which could reduc synapt plastic insulin transport brain reduc age some anim model type 2 diabet brain insulin resist may present well studi examin effect hyperinsulin clamp intranas insulin cognit function have found small consist improv memori chang brain neuroelectr paramet evok brain potenti consist improv attent memori process these effect appear due rais brain insulin level peripher level insulin growth factori igfi associ glucos regul influenc glucos dispos there some indic reduc sensit insulin igfi brain observ age obes diabet decreas clearanc amyloid such decreas involv insulin receptor cascad can also increas amyloid toxic insulin igfi may modul brain level insulin degrad enzym which would also lead accumul amyloid

Claude  Messier

Kevin  Teutenberg

The Role of Insulin, Insulin Growth Factor, and Insulin-Degrading Enzyme in Brain Aging and Alzheimer&#39;s Disease

system administ human recombin erythropoietin epo may have potenti reduc cognit behavior symptom mechan brain injuri seri studi address possibl previous found epo given fimbriafornix transect rat moment injuri could substanti improv posttraumat acquisit allocentr place learn task when task administ water maze due clinic import result import scrutin whether therapeut effect epo specif experiment setup our origin experi general across test situat consequ here studi effect similar administ epo fimbriafornix transect control oper rat respect evalu posttraumat behavior cognit abil allocentr place learn task administ 8arm radial maze the administr epo hippocamp injur rat associ virtual complet elimin otherwis sever behavior impair caus fimbriafornix transect contrast epo had detect effect task acquisit nonles anim the result present studi confirm our previous demonstr epo abil reduc elimin behavior cognit consequ mechan injuri hippocampus while ad import observ therapeut effect restrict specif experiment setup previous studi

Hana  Malá

Carina Gili Alsina

Kathrine Skak Madsen

Else la Cour Sibbesen

Henriette  Stick

Jesper  Mogensen

Erythropoietin Improves Place Learning in an 8-Arm Radial Maze in Fimbria-Fornix Transected Rats

current minireview focus genet mous model alzheimer diseas becaus various excel uptod review special issu reliabl websit alreadi dedic genet alzheimer diseas general anim model particular review meant comprehens rather aim steer alzheimer novic through recent mous literatur special attent paid genet model have been test behavior

Yann S. Mineur

Declan  McLoughlin

Wim E. Crusio

Frans  Sluyter

Genetic Mouse Models of Alzheimer&#39;s Disease

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Neural Plasticity is an interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology.

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Chief Editor, Professor Baudry, is currently University Professor at Western University of Health Sciences in Pomona, CA. His research focuses on understanding the molecular/cellular mechanisms of learning and memory and neurodegeneration.

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Neural Plasticity

Pathological Changes in Memory Processing

Pathological Changes in Memory Processing

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Interaction Between Emotion and Memory: Importance of Mammillary Bodies Damage in a Mouse Model of the Alcoholic Korsakoff Syndrome