Neural Plasticity

Perineuronal Nets and CNS Plasticity and Repair


Status
Published

Lead Editor

1University of Turin, Turin, Italy

2University of Cambridge, Cambridge, UK

3University of Florence, Florence, Italy


Perineuronal Nets and CNS Plasticity and Repair

Description

The extracellular matrix (ECM) of the nervous system provides a microenvironment that regulates numerous events during development, influencing neurogenesis, gliogenesis, cell migration, axonal outgrowth, and circuitry formation, as well as in adulthood, affecting cell survival, plasticity, damage responses, and regeneration.There are substantial changes in the quantity and the composition of the ECM during the course of development, particularly at the end of critical periods, i.e., temporal windows of superior structural and functional synaptic plasticity. Here, cartilage-like structures called perineuronal nets (PNNs) deposit around many types of neuron, helping in stabilizing the established neuronal connections. In recent years, several other functions of the PNNs have been disclosed, including restriction of neuronal plasticity, neuronal protection, and modulation of the pathogenesis of various CNS diseases, such as Alzheimer’s disease, epilepsy, and schizophrenia. The mechanisms through which PNNs act remain unclear, although recent advances promise to shed additional light on this important subject. A better understanding of the structure and function of PNNs in physiological and pathological conditions and of the consequences of manipulating the PNN has clearly a strong potential for the development of therapies to enhance neuronal plasticity and functional recovery after CNS damage.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the role of PNNs in brain physiology and pathology.

Potential topics include, but are not limited to:

  • Molecular contributors to PNN structure and function
  • Role of PNNs in the regulation of neuronal function
  • PNNs and plasticity in various cortical areas
  • Changes of PNNs during structural plasticity, homeostatic plasticity, and learning/memory
  • Role of PNNs in CNS disease, including schizophrenia, Alzheimer's disease, stroke, and neurodevelopmental disorders

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4327082
  • - Editorial

Perineuronal Nets and CNS Plasticity and Repair

Daniela Carulli | Jessica C. F. Kwok | Tommaso Pizzorusso
  • Special Issue
  • - Volume 2016
  • - Article ID 7538208
  • - Review Article

Caught in the Net: Perineuronal Nets and Addiction

Megan Slaker | Jordan M. Blacktop | Barbara A. Sorg
  • Special Issue
  • - Volume 2016
  • - Article ID 3679545
  • - Review Article

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

F. de Winter | J. C. F. Kwok | ... | J. Verhaagen
  • Special Issue
  • - Volume 2016
  • - Article ID 1305801
  • - Research Article

Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan

Shinji Miyata | Hiroshi Kitagawa
  • Special Issue
  • - Volume 2016
  • - Article ID 7931693
  • - Review Article

Otx2-PNN Interaction to Regulate Cortical Plasticity

Clémence Bernard | Alain Prochiantz
  • Special Issue
  • - Volume 2016
  • - Article ID 5214961
  • - Review Article

Neuron-Glia Interactions in Neural Plasticity: Contributions of Neural Extracellular Matrix and Perineuronal Nets

Egor Dzyubenko | Christine Gottschling | Andreas Faissner
  • Special Issue
  • - Volume 2016
  • - Article ID 6021428
  • - Research Article

Distribution of N-Acetylgalactosamine-Positive Perineuronal Nets in the Macaque Brain: Anatomy and Implications

Adrienne L. Mueller | Adam Davis | ... | Farrel R. Robinson
  • Special Issue
  • - Volume 2016
  • - Article ID 9847696
  • - Review Article

In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders

Harry Pantazopoulos | Sabina Berretta
  • Special Issue
  • - Volume 2016
  • - Article ID 2828536
  • - Research Article

Reorganization of Synaptic Connections and Perineuronal Nets in the Deep Cerebellar Nuclei of Purkinje Cell Degeneration Mutant Mice

M. Blosa | C. Bursch | ... | M. Morawski
  • Special Issue
  • - Volume 2015
  • - Article ID 256389
  • - Research Article

Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain

Noriko Horii-Hayashi | Takayo Sasagawa | ... | Mayumi Nishi
Neural Plasticity
 Journal metrics
Acceptance rate43%
Submission to final decision66 days
Acceptance to publication42 days
CiteScore3.330
Impact Factor3.591
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