Neural Plasticity

New Insights into the Role of the Locus Coeruleus-Noradrenergic System in Memory and Perception Dysfunction


Status
Published

Lead Editor

1University of Bonn, Bonn, Germany

2Max Planck Institute for Biological Cybernetics, Tübingen, Germany

3Federal University of Pampa, Uruguaiana, Brazil


New Insights into the Role of the Locus Coeruleus-Noradrenergic System in Memory and Perception Dysfunction

Description

The locus coeruleus (LC) is a nucleus in the brainstem and the main origin of noradrenaline (NA) in the brain connected to memory-relevant regions such as the hippocampus. The LC-NA system is decisive for modulating hippocampal long-term plasticity and crucial for memory engrams. The LC is known to be one of the primary sites of neurodegeneration in patients with Alzheimer’s disease and in animal models of Alzheimer’s disease. One of the leading symptoms of Alzheimer´s disease is memory dysfunction. LC parameters have recently been discovered to be novel biomarkers in dementia. Furthermore, the LC-NA system is important for perception.

We invite authors to delineate the pathophysiological role of the LC-NA system in memory and perception dysfunction and in demential disorders in the form of original research articles, theories, method protocols, and classifications. Basic knowledge might be translated into a clinical research framework. Basic research studies, reviews, and perspectives are welcome, as are studies of applied research.

Potential topics include but are not limited to the following:

  • Characterization of the activation/ deactivation of the locus coeruleus in order to modulate neural plasticity relevant for memory and/or perception dysfunction
  • Recent discoveries of the locus coeruleus-noradrenaline system on different levels such as behavioral, morphological, molecular, and network with relevant aspects for memory and/or perception dysfunction
  • Novel methodological approaches such as optogenetics or neuroimaging protocols to delineate the role of the locus coeruleus in memory and/or perception dysfunction
  • Structural and functional interactions of the locus coeruleus-noradrenaline system with the hippocampus concerning memory dysfunction
  • Neurobiology of the locus coeruleus in Alzheimer’s disease and other synaptopathies with memory disturbances

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4624171
  • - Editorial

New Insights into the Role of the Locus Coeruleus-Noradrenergic System in Memory and Perception Dysfunction

O. Eschenko | P. B. Mello-Carpes | N. Hansen
  • Special Issue
  • - Volume 2017
  • - Article ID 8602690
  • - Review Article

Locus Coeruleus and Dopamine-Dependent Memory Consolidation

Miwako Yamasaki | Tomonori Takeuchi
  • Special Issue
  • - Volume 2017
  • - Article ID 7829507
  • - Review Article

Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus

Termpanit Chalermpalanupap | David Weinshenker | Jacki M. Rorabaugh
  • Special Issue
  • - Volume 2017
  • - Article ID 6817349
  • - Review Article

Genesis and Maintenance of Attentional Biases: The Role of the Locus Coeruleus-Noradrenaline System

Mana R. Ehlers | Rebecca M. Todd
  • Special Issue
  • - Volume 2017
  • - Article ID 2727602
  • - Review Article

The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System

Niels Hansen
  • Special Issue
  • - Volume 2017
  • - Article ID 4328015
  • - Review Article

Could LC-NE-Dependent Adjustment of Neural Gain Drive Functional Brain Network Reorganization?

Carole Guedj | David Meunier | ... | Fadila Hadj-Bouziane
  • Special Issue
  • - Volume 2017
  • - Article ID 6031478
  • - Review Article

Noradrenergic Modulation of Cognition in Health and Disease

Olga Borodovitsyna | Matthew Flamini | Daniel Chandler
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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