Neural Plasticity

Peripheral Nerve Injury and Repair: Plasticity from Muscle to Brain


Publishing date
01 Jul 2021
Status
Closed
Submission deadline
12 Mar 2021

Lead Editor

1Huashan Hospital, Fudan University, Shanghai, China

2Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

3Wake Forest School of Medicine, Winston-Salem, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Peripheral Nerve Injury and Repair: Plasticity from Muscle to Brain

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Peripheral nerve injuries (PNIs) by traumatic or nontraumatic causes lead to significant sensorimotor function loss and pain. Although there have been surgical technical improvements (e.g., nerve transfer) over the last few decades, we have not seen significant progress in the management or rehabilitation strategies in patients with PNIs. Clinicians continue to face the challenges of significant sensorimotor deficits, disabling neuropathic pain, allodynia, hyperalgesia, referred pain, and other somatosensory abnormalities.

In brief, the term “plasticity” refers to the ability to change. In the field of neuroscience, studies of plasticity examine changes in the structure or function of the nervous system from the molecular/cellular (e.g., channels, receptors, synapses, neurons) to systemic level (e.g., networks, connections), including both the peripheral (peripheral neuroplasticity) and central nervous system (central neuroplasticity). The extensive “plastic changes” at multiple levels, including cortex, subcortex, spinal cord, nerve trucks, and muscles, occur during the repair and recovery process of PNIs and contribute to the restoration outcomes of sensorimotor function. Better understanding of the contribution of plasticity to the symptoms in recovering PNI patients could help guide rehabilitation strategies and inform the development of novel techniques to counteract these maladaptive changes and ultimately improve outcomes.

This Special Issue aims to provide an inter- and multi-disciplinary overview of the research in the field of neuroplasticity that can occur in peripheral and central nervous systems after injury to a peripheral nerve. Following peripheral nerve injury and repair, we firstly focus on topics of peripheral nerve regeneration and target muscle reinnervation. We are interested in how axons grow through the injured site and new motor endplates form. Influencing factors (e.g., neurotrophic factors) and interventions to promote axon regeneration and prevent muscle atrophy can be included. We are even more interested in topics on plastic changes in the central nervous system following PNI. Subjects may cover structures including cortex (e.g., sensorimotor representation changes, increase/decrease of cortical excitability, changes in synaptic efficiency), subcortex (e.g., reorganization of afferent/efferent projections, remolding of neural circuits, changes in ion channels) and spinal cord (e.g., dendrite and neuron remolding, plasticity of synapsis, changes in inhibitory neurons). We encourage in vitro and in vivo studies, animal studies, and clinical investigations. We welcome original research articles, reviews, protocols and case reports. The aim of this special issue is to explore the mechanism of plasticity after PNIs and develop potentially effective strategies for functional recovery in both animal models and humans.

Potential topics include but are not limited to the following:

  • Brachial plexus Injury
  • Traumatic peripheral nerve Injury
  • Peripheral nerve entrapment
  • Peripheral neuritis
  • Glia cells (astrocytes, microglia, oligodendrocytes, Schwann cells)
  • Diabetic peripheral neuropathy
  • Brain plasticity after peripheral nerve injury
  • Remolding of neural circuits
  • Spinal cord plasticity after peripheral nerve Injury
  • Nerve degeneration and regeneration
  • Muscle atrophy
  • Novel surgical treatments for peripheral nerve injury
  • Novel rehabilitation treatments for peripheral nerve injury

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9959103
  • - Research Article

Diabetic Peripheral Neuropathy Affects Pinch Strength and Hand Dexterity in Elderly Patients

Qi Zhang | Yifang Lin | ... | Jie Jia
  • Special Issue
  • - Volume 2021
  • - Article ID 6678863
  • - Research Article

Restoration of Deafferentation Reduces Tinnitus, Anxiety, and Depression: A Retrospective Study on Cochlear Implant Patients

Juanmei Yang | Jing Song | ... | Zhao Han
  • Special Issue
  • - Volume 2021
  • - Article ID 5513224
  • - Research Article

Model-Based Analysis of Muscle Strength and EMG-Force Relation with respect to Different Patterns of Motor Unit Loss

Chengjun Huang | Maoqi Chen | ... | Ping Zhou
  • Special Issue
  • - Volume 2021
  • - Article ID 6690414
  • - Research Article

Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Shengyang Ge | Qingfeng Hu | ... | Chuanyu Sun
  • Special Issue
  • - Volume 2021
  • - Article ID 8831379
  • - Research Article

Changes in Temporal and Spatial Patterns of Intrinsic Brain Activity and Functional Connectivity in Upper-Limb Amputees: An fMRI Study

Bingbo Bao | Lei Duan | ... | Xianyou Zheng
  • Special Issue
  • - Volume 2021
  • - Article ID 8819169
  • - Research Article

Focal Vibration Alters Human Digital Sensory Nerve Action Potentials: A Pilot Study

Dong Qing Zhu | Fang Liu | ... | Xiang Jun Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 8854461
  • - Research Article

Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy

Chieh-Hsin Wu | Ming-Kung Wu | ... | Chih-Lung Lin
  • Special Issue
  • - Volume 2021
  • - Article ID 6684176
  • - Research Article

Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model

Wei Wang | Yunhao Wang | ... | Shenghe Liu
  • Special Issue
  • - Volume 2021
  • - Article ID 6649135
  • - Research Article

Predicting Upcoming Events Occurring in the Space Surrounding the Hand

Maria L. Rangel | Lidiane Souza | ... | Claudia D. Vargas
  • Special Issue
  • - Volume 2021
  • - Article ID 6689476
  • - Research Article

Impaired Limb Functional Outcome of Peripheral Nerve Regeneration Is Marked by Incomplete Recovery of Paw Muscle Atrophy and Brain Functional Connectivity in a Rat Forearm Nerve Repair Model

Qiyuan Bao | Qi Liu | ... | Weibin Zhang
Neural Plasticity
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Acceptance rate53%
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Acceptance to publication37 days
CiteScore5.200
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