Neural Plasticity

Glial Cells and Synaptic Plasticity


Status
Published

1University of Rochester Medical Center, Rochester, USA

2Texas A&M HSC College of Medicine, Temple, USA

3Nanjing Normal University, Nanjing, China

4São Paulo State University (UNESP), São Paulo, Brazil

5University of Manchester, Manchester, UK


Glial Cells and Synaptic Plasticity

Description

Historically, glial cells were thought to provide only metabolic and physical support for neurons, serving as the primary source of energy for neurons and controlling the ionic homeostasis. In the past decades, many studies have discovered more important roles of astrocytes, including providing energetic substrate to neurons, taking up neurotransmitters, maintaining ion homeostasis, releasing gliotransmitters, and signaling molecules as well as maintaining and regulating the extracellular matrix. Structurally, Astrocytes have irregularly shaped cell bodies and are characterized by an abundance of leaflet-like processes, enwrap most synapses to form a tripartite in the CNS, and exhibit remarkable plasticity resulting from crosstalk. The interactions within the tripartite are dynamic are required for normal synaptic physiology and plasticity, as well as for the development and refinement of the neuronal circuit. Recent reports have also demonstrated that astrocytes can actively regulate synapses with intracellular Ca2+ wave regulated signaling pathways. Although much progress has been made in our understanding the cellular and molecular mechanisms and ongoing research are adding new information, but we are still at the early stage of understanding the relationship between astrocytes and synaptic plasticity, and new questions are still emerging regarding the role of glial cells in the CNS development, function, and diseases. For example, even though many astrocytic changes are found during pathological conditions, it is still unknown whether the astrocytic changes induced the disease or the reverse.

In this special issue, we invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to seek to understand the relationship between glial and neural plasticity, with a particular focus on astrocytes and microglial cells.

Potential topics include, but are not limited to:

  • Astrocytic/microglial changes and synaptic plasticity in physiological and pathological conditions
  • The mechanisms of glial cells modulating synaptic plasticity in physiological and pathological conditions, such as D-serine, homeostasis, glutamate, ATP, and lipid
  • The treatment of the glial cells in pathological conditions, such as Alzheimer’s, Parkinson’s, epilepsy, and depression
  • New methods of imaging studies that directly show the roles of astrocyte in the synapse changes, such as Channelrhodopsin studies
  • Neuromodulators with astrocytes/microglia and synapse changes

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5042902
  • - Editorial

Glial Cells and Synaptic Plasticity

Fushun Wang | Tifei Yuan | ... | Jason H. Huang
  • Special Issue
  • - Volume 2016
  • - Article ID 1347987
  • - Research Article

Astrocyte Hypertrophy Contributes to Aberrant Neurogenesis after Traumatic Brain Injury

Clark Robinson | Christopher Apgar | Lee A. Shapiro
  • Special Issue
  • - Volume 2016
  • - Article ID 7607924
  • - Research Article

Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study

Maurizio De Pittà | Nicolas Brunel
  • Special Issue
  • - Volume 2016
  • - Article ID 4959523
  • - Review Article

Role of MicroRNA in Governing Synaptic Plasticity

Yuqin Ye | Hongyu Xu | ... | Xiaosheng He
  • Special Issue
  • - Volume 2016
  • - Article ID 3928726
  • - Research Article

Housing Complexity Alters GFAP-Immunoreactive Astrocyte Morphology in the Rat Dentate Gyrus

Garrick Salois | Jeffrey S. Smith
  • Special Issue
  • - Volume 2016
  • - Article ID 4129015
  • - Research Article

Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway

Peng Sun | Sheng Wei | ... | Jibiao Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 8941327
  • - Review Article

Recent Advance in the Relationship between Excitatory Amino Acid Transporters and Parkinson’s Disease

Yunlong Zhang | Feng Tan | ... | Shaogang Qu
  • Special Issue
  • - Volume 2016
  • - Article ID 7192427
  • - Review Article

The Plastic Glial-Synaptic Dynamics within the Neuropil: A Self-Organizing System Composed of Polyelectrolytes in Phase Transition

Vera Maura Fernandes de Lima | Alfredo Pereira
  • Special Issue
  • - Volume 2016
  • - Article ID 1680905
  • - Review Article

Glia and TRPM2 Channels in Plasticity of Central Nervous System and Alzheimer’s Diseases

Jing Wang | Michael F. Jackson | Yu-Feng Xie
  • Special Issue
  • - Volume 2016
  • - Article ID 2412958
  • - Research Article

Value of Functionalized Superparamagnetic Iron Oxide Nanoparticles in the Diagnosis and Treatment of Acute Temporal Lobe Epilepsy on MRI

Tingting Fu | Qingxia Kong | ... | Lingyun Gao
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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