Neural Plasticity

Stress Induced Neuroplasticity and Mental Disorders


Status
Published

Lead Editor

1Nanjing University of Chinese Medicine, Nanjing, China

2Shandong University, Shandong, China

3Texas A&M University, College Station, USA

4Scott and White, Temple, USA


Stress Induced Neuroplasticity and Mental Disorders

Description

Stress induced neuroplasticity plays a critical role in almost all of the mental disorders. Some stress induced changes are long-term: for example, the childhood stress induced changes can persist into adulthood to induce mental disorders, such as depression, or posttraumatic stress disorders. Stress can be defined as the presence of acute or persistent physiological or psychological threats to the organism that results in significant strain on the body’s compensatory systems. Stress is further characterized by the existence of compensatory responses that generally deviate from and extend normal physiological regulation in order to protect the living organism against severe threats and sustain life. Based on the clinical and preclinical evidence, the elucidation of the precise mechanisms underlying how psychological and physical stressors can influence the CNS and peripheral organ systems as well as the development of systemic diseases remains unsolved. To date, activation of the hypothalamic-pituitary-adrenal (HPA) axis has been widely accepted as one of the central mechanisms involved in stress regulating neural plasticity, which is critical to the understanding of the mental disorders as well as cognitive functions.

In all, mental disorders are among the leading causes of disabilities worldwide. Stress is the major reason for almost all these mental disorders and has become a synonym for diverse terms of negative emotions, such as anxiety or threat. The mechanism might be stress induced neural plasticity, including the hormones and neuromodulators, which in turn can alter the function of the neural networks, by altering the networks’ building blocks and by altering the dynamics and integrative properties, and thus the behavior or emotional changes.

In this special issue, we invite investigators to contribute original research articles as well as review articles that focus on stress induced neural plasticity in mental disorders. The targeted readouts could be molecular, behavioral, or systematic level. This special issue is intended to link preclinical to clinical work and to provide an outlook to potential plasticity-modulating treatments in the future.

Potential topics include but are not limited to the following:

  • Preclinical and animal investigations of stress induced neural plasticity in genetic or other mental disorder models
  • Clinical studies about the psychological and emotional changes that trigger mental disorders, such as depression, ADHD, chronic pain, psychosis, and even ageing
  • Investigations to understand the variability of neural plasticity responses in affected brains
  • The pharmacological modulation of stress induced neuroplasticity and thus the mental disorders
  • Impact of various modulators such as drugs on the molecular cellular or physiological mechanisms of stress induced neural plasticity

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 9634501
  • - Editorial

Stress Induced Neuroplasticity and Mental Disorders

Fushun Wang | Fang Pan | ... | Jason H. Huang
  • Special Issue
  • - Volume 2017
  • - Article ID 3710821
  • - Research Article

A Combined Water Extract of Frankincense and Myrrh Alleviates Neuropathic Pain in Mice via Modulation of TRPV1

Danyou Hu | Changming Wang | ... | Zongxiang Tang
  • Special Issue
  • - Volume 2017
  • - Article ID 3270725
  • - Research Article

Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer’s Disease

Lingyan Xu | Zhiyun Ren | ... | Yuesong Gong
  • Special Issue
  • - Volume 2017
  • - Article ID 6537230
  • - Research Article

Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability

Mingqi Qiao | Peng Sun | ... | Jibiao Wu
  • Special Issue
  • - Volume 2017
  • - Article ID 9382797
  • - Research Article

Neuroplastic Correlates in the mPFC Underlying the Impairment of Stress-Coping Ability and Cognitive Flexibility in Adult Rats Exposed to Chronic Mild Stress during Adolescence

Yu Zhang | Feng Shao | ... | Weiwen Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 6402942
  • - Review Article

The Role of Stress Regulation on Neural Plasticity in Pain Chronification

Xiaoyun Li | Li Hu
  • Special Issue
  • - Volume 2016
  • - Article ID 8072156
  • - Research Article

Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway

Yuqin Ye | Zhenyu Zhao | ... | Xiaosheng He
  • Special Issue
  • - Volume 2016
  • - Article ID 8928530
  • - Research Article

ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro

Fuxing Yang | Kai Zhao | ... | Bainan Xu
  • Special Issue
  • - Volume 2016
  • - Article ID 8058093
  • - Review Article

Safety Needs Mediate Stressful Events Induced Mental Disorders

Zheng Zheng | Simeng Gu | ... | Fushun Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 7950781
  • - Research Article

Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing and Expression in the Rat Brain

Fang Li | Jizhen Feng | ... | Mingqi Qiao
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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