Neural Plasticity

The Many Faces of Stress: Implications for Neuropsychiatric Disorders


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Published

Lead Editor
Guest Editors

1Università degli Studi di Milano, Milano, Italy

2Rockefeller University, New York, USA


The Many Faces of Stress: Implications for Neuropsychiatric Disorders

Description

Environmental stress is widely recognized as one of the main risk factors for neuropsychiatric diseases, including mood and anxiety disorders. Stress, with the ensuing activation of the hypothalamic-pituitary-adrenal axis, deeply affects neurotransmission and synaptic morphology in brain areas associated with behavior and mental states. Clinical and preclinical studies have reported that the impact of stressful life events on the emotional and cognitive behavior may vary depending on the nature of stress and its intensity or duration, as well as the time window of development during which stress exposure occurs (perinatally, adolescence, adulthood, or ageing). Importantly, the many-sided faces of stress also depend on brain regions, sex, and individual differences. This multifaceted picture is integrated by the biphasic effect of stress that strictly depends on the duration of stress exposure. Indeed, while the fast response to stress includes plasticity enhancing effects associated with improved cognition, the long-term adaptive changes induced by stress, in particular following chronic stress, can be deleterious, leading to impaired function, enhanced susceptibility, or triggering of mood and anxiety disorders.

We invite investigators to contribute original research articles as well as review articles that highlight the multifaceted impact of stress and glucocorticoids on synaptic transmission, neuroplasticity, gene expression, cognition, and behavior. We are particularly interested in articles describing the time-dependent functional, cellular, morphological, and behavioral consequences of acute and chronic physical or psychological stress in brain areas involved in stress response, throughout lifespan. This special issue is intended to collect findings highlighting the idea that the understanding of the pathophysiology of stress-related pathologies (especially mood and anxiety disorders) must include an integrated approach, from the molecules to behavior, embracing the plasticity of the ever-changing brain in mammals.

Potential topics include, but are not limited to:

  • Fast, delayed, and long-lasting effects of acute or chronic physical or psychological stress on neuronal plasticity, gene expression, and behavior
  • Adaptive mechanisms induced by stress and their molecular underpinnings
  • Impact of stress on neuroplasticity and behavior throughout lifespan (perinatally, adolescence, adulthood, or ageing)
  • Epigenetic reprogramming induced by stress
  • Individual susceptibility to stress
  • Stress resilience and sex differences
  • Peripheral versus central mediators of stress related neuronal plasticity in the brain

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8389737
  • - Editorial

The Many Faces of Stress: Implications for Neuropsychiatric Disorders

Laura Musazzi | Jordan Marrocco
  • Special Issue
  • - Volume 2016
  • - Article ID 5054275
  • - Research Article

Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats

Jiro Kasahara | Hiroto Uchida | ... | Nanae Oka
  • Special Issue
  • - Volume 2016
  • - Article ID 6752193
  • - Review Article

Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

Laura Musazzi | Jordan Marrocco
  • Special Issue
  • - Volume 2016
  • - Article ID 5460732
  • - Review Article

Comorbidity Factors and Brain Mechanisms Linking Chronic Stress and Systemic Illness

Vanja Duric | Sarah Clayton | ... | Li-Lian Yuan
  • Special Issue
  • - Volume 2016
  • - Article ID 7267865
  • - Research Article

Acute Footshock Stress Induces Time-Dependent Modifications of AMPA/NMDA Protein Expression and AMPA Phosphorylation

Daniela Bonini | Cristina Mora | ... | Alessandro Barbon
  • Special Issue
  • - Volume 2016
  • - Article ID 7539065
  • - Review Article

Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders

Ignacio Negrón-Oyarzo | Francisco Aboitiz | Pablo Fuentealba
  • Special Issue
  • - Volume 2016
  • - Article ID 3985063
  • - Review Article

Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders

Freddy Jeanneteau | Margarita Arango-Lievano
  • Special Issue
  • - Volume 2016
  • - Article ID 2540462
  • - Review Article

Lasting Differential Effects on Plasticity Induced by Prenatal Stress in Dorsal and Ventral Hippocampus

Gayane Grigoryan | Menahem Segal
  • Special Issue
  • - Volume 2016
  • - Article ID 6503162
  • - Review Article

Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism

E. R. de Kloet | M. L. Molendijk
  • Special Issue
  • - Volume 2016
  • - Article ID 6212983
  • - Research Article

Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice

Alessandro Ieraci | Alessandra Mallei | Maurizio Popoli
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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