Neural Plasticity

Neuroplasticity in the Pathology of Neurodegenerative Diseases


Publishing date
01 May 2019
Status
Published
Submission deadline
28 Dec 2018

1Poznan University of Medical Sciences, Poznan, Poland

2Nencki Institute of Experimental Biology, Warsaw, Poland

3California Northstate University, Elk Grove, USA

4University of Melbourne, Melbourne, Australia


Neuroplasticity in the Pathology of Neurodegenerative Diseases

Description

Neuroplasticity is a primary property of the nervous system and is not only able to restore its function but can also alleviate the onset of developmental disorders. Neural plasticity appears in response to various internal and external causes, including stroke, epilepsy, neurodegenerative diseases, and pharmacological treatment (e.g., L-dopa, antiepileptic drugs).

Cerebrovascular diseases, including stroke, micro stroke, and hemorrhagic stroke, lead to a change in the protein profile involved in the compensatory mechanisms of oxidative stress, apoptosis, a release of neurotransmitters, and assembly of the cytoskeleton, as well as neuroplasticity and cognitive function.

Moreover, it has been demonstrated that many stimuli, such as injuries or illnesses (e.g., epilepsy), may induce neuroplasticity. Epilepsy and neuroplasticity seem to be closely related, as the two processes could positively affect one another.

Neuroplasticity arises as a consequence of degenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. It is known that these diseases may lead to disorders of synaptic transmission depending on the degree and extent of the central nervous system lesions.

However, patterns of neural plasticity following brain ischemia and degenerative diseases are almost unknown. It seems that both structural disorders and pharmacotherapy play an important role in normal central nervous transmission. The authors are also welcome to submit the manuscripts on research giving insight into the new therapies supporting the central nervous system plasticity in neurodegenerative diseases.

It seems that understanding of the brain plasticity mechanisms may contribute to more effective therapies and improve the lifestyle of patients with neurodegenerative diseases.

Potential topics include but are not limited to the following:

  • Molecular factors involved in APP processing, as well as growth factors, serotoninergic system, cholinergic neurotransmission, and synaptic plasticity of the dementia diseases
  • Parkinsonism-linked genes, oxidative stress, L-dopa pharmacotherapy, and neuronal signaling or plasticity in Parkinson’s disease
  • Loss of synaptic plasticity due to mutant huntingtin and mitochondrial dysfunction in Huntington’s disease
  • The protein fractions participating in exocytosis, synaptic plasticity/signaling, and support of neurotransmitter transport after stroke
  • Abnormal structural modifications in childhood epilepsy and as a result of another neurodegenerative diseases or an acute brain injury in adult epilepsy as well as antiepileptic drug pharmacotherapy and neuroplasticity
  • Neurogenesis in the neurodegenerative diseases

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 4245821
  • - Editorial

Neuroplasticity in the Pathology of Neurodegenerative Diseases

Jolanta Dorszewska | Wojciech Kozubski | ... | Kevin Ong
  • Special Issue
  • - Volume 2020
  • - Article ID 1859431
  • - Review Article

Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective

Lucas Udovin | Cecilia Quarracino | ... | Santiago Perez-Lloret
  • Special Issue
  • - Volume 2019
  • - Article ID 4209475
  • - Review Article

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Tomasz Jaworski | Ewa Banach-Kasper | Katarzyna Gralec
  • Special Issue
  • - Volume 2019
  • - Article ID 8215017
  • - Research Article

Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease

Ewelina Palasz | Wiktor Niewiadomski | ... | Grazyna Niewiadomska
  • Special Issue
  • - Volume 2019
  • - Article ID 6286197
  • - Research Article

Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity

Dwaine F. Emerich | Jeffrey H. Kordower | ... | Lars U. Wahlberg
  • Special Issue
  • - Volume 2019
  • - Article ID 9708905
  • - Review Article

Brain Functional Reserve in the Context of Neuroplasticity after Stroke

Jan Dąbrowski | Anna Czajka | ... | Andrzej Ziemba
  • Special Issue
  • - Volume 2019
  • - Article ID 7143458
  • - Research Article

New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation Sequencing

Wu Li | Lingyun Mei | ... | Yong Feng
  • Special Issue
  • - Volume 2018
  • - Article ID 8423420
  • - Review Article

Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome

Fei Gao | Lijun Qi | ... | Huan Zhao
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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