Neural Plasticity

Interventions to Enhance Adaptive Plasticity after Stroke: From Mechanisms to Therapeutic Perspectives


Status
Published

1Sao Paulo University, Sao Paulo, Brazil

2University of Surrey, Surrey, UK

3Cleveland Clinic, Cleveland, USA

4National Institute of Neurological Disorders and Stroke, Bethesda, USA


Interventions to Enhance Adaptive Plasticity after Stroke: From Mechanisms to Therapeutic Perspectives

Description

Stroke is a leading cause of disability worldwide. Specific rehabilitation interventions, invasive and noninvasive neuromodulation tools, have emerged aiming at enhancement of adaptive plasticity processes and downregulation of postlesional maladaptive plasticity. Attempts to translate potentiation of adaptive plasticity into effective therapeutic strategies have been faced with numerous challenges, such as heterogeneity in clinical characteristics, lesions, and outcomes, as well as barriers to conducting appropriately powered studies. Technical challenges related to the methods for applying neuromodulation via invasive or noninvasive systems have also been numerous. Finally, the current understanding of how animal models may inform or correlate with posttranslational clinical trials remains limited. Current knowledge suggests that understanding mechanisms underlying recovery in different patients and across the translational bridge is crucial to tailor treatments and hence develop successful interventions to enhance clinically meaningful outcomes.

We invite investigators to contribute with original research articles or review articles that focus on investigation of mechanisms underlying effects of rehabilitation interventions in stroke in humans or animals, as well on evaluation of these effects, current knowledge, and gaps that must be addressed.

We are particularly interested in studies that describe the use of preclinical, clinical, imaging, and neurophysiology tools, as well as studies that integrate different approaches to address effects of rehabilitation strategies in stroke rehabilitation or recovery.

Potential topics include, but are not limited to:

  • Recent developments in the use of repetitive transcranial magnetic stimulation, transcranial direct current stimulation, repetitive electrical nerve stimulation, pharmacological modulation, or combinations of these interventions, in motor performance, cognition, pain, functional independence, quality of life, or other outcomes in patients with stroke
  • Advances in understanding mechanisms underlying effects, or in developing safe and effective protocols of deep brain stimulation or invasive direct cortical stimulation
  • Other specific interventions to enhance adaptive plasticity after stroke such as imagery, biofeedback, meditation, virtual reality, robotics, and constraint-induced movement therapy, among others
  • Translational studies in animal models of ischemia or focal injury. These may be preclinical trials or mechanistic or physiological studies aimed at better informing the use of invasive or noninvasive neuromodulation to promote poststroke rehabilitation
  • Animal or human studies about the role of stem cells in restoration of function or recovery after stroke
  • Specificities of paradigms that lead to best results in enhancing stroke outcomes
  • Roles of age, time from lesion onset, stroke etiology, lesion side, site, and structural and functional connectivity in responsiveness to neuromodulation
  • Safety and potential neuroprotective or deleterious effects of rehabilitation interventions at different stages after stroke
  • Duration of plastic changes associated with rehabilitation interventions in animals and humans

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 9153501
  • - Editorial

Interventions to Enhance Adaptive Plasticity after Stroke: From Mechanisms to Therapeutic Perspectives

Adriana Conforto | Annette Sterr | ... | Leonardo Cohen
  • Special Issue
  • - Volume 2016
  • - Article ID 4192718
  • - Research Article

The Neural Correlates of Long-Term Carryover following Functional Electrical Stimulation for Stroke

Marta Gandolla | Nick S. Ward | ... | Alessandra Pedrocchi
  • Special Issue
  • - Volume 2016
  • - Article ID 4071620
  • - Review Article

Models to Tailor Brain Stimulation Therapies in Stroke

E. B. Plow | V. Sankarasubramanian | ... | A. G. Machado
  • Special Issue
  • - Volume 2016
  • - Article ID 4796906
  • - Research Article

Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia

Joseph C. Griffis | Rodolphe Nenert | ... | Jerzy P. Szaflarski
  • Special Issue
  • - Volume 2016
  • - Article ID 3034963
  • - Research Article

Is the Frequency in Somatosensory Electrical Stimulation the Key Parameter in Modulating the Corticospinal Excitability of Healthy Volunteers and Stroke Patients with Spasticity?

Marco Antonio Cavalcanti Garcia | João Marcos Yamasaki Catunda | ... | Claudia D. Vargas
  • Special Issue
  • - Volume 2016
  • - Article ID 8176217
  • - Review Article

Upper Limb Immobilisation: A Neural Plasticity Model with Relevance to Poststroke Motor Rehabilitation

Leonardo Furlan | Adriana Bastos Conforto | ... | Annette Sterr
Neural Plasticity
 Journal metrics
Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore6.900
Impact Factor3.093
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