Neural Plasticity

Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2020


Publishing date
01 Sep 2020
Status
Published
Submission deadline
24 Apr 2020

Lead Editor

1Southeast University, Nanjing, China

2University of Massachusetts Amherst, Amherst, USA

3Dalhousie University, Halifax, Canada

4University of Tampere, Tampere, Finland

5Tulane University, Louisiana, USA


Reestablishing Neural Plasticity in Regenerated Spiral Ganglion Neurons and Sensory Hair Cells for Hearing Loss 2020

Description

Hearing loss is considered the most common sensory disorder in the human population that occurs at all ages worldwide, and sensorineural hearing loss (SNHL) is the most common type of hearing loss. Various insults could induce SNHL, including acoustic trauma, ear and brain tumors, aging, noise exposure, or ototoxic medications or chemicals. SNHL is caused by the irreversible loss of sensory hair cells and the degeneration of the spiral ganglion neurons. SNHL is not yet curable because of the irreversible death of hair cells and the degeneration of spiral ganglion neurons in the cochlea. Recent years, exciting animal studies on signaling pathway manipulation, gene therapy, and stem cell transplantation as well as pharmaceutical agents demonstrated that hair cells and spiral ganglion neurons could be regenerated and indicated that hearing loss might eventually be curable in the future. Neural plasticity is a key feature for spiral ganglion neurons and hair cells and is especially important for the new regenerated spiral ganglion neurons and hair cells. This special issue will focus on recent advances in reestablishing the neural plasticity of regenerated spiral ganglion neurons and sensory hair cells.

In this Special Issue, we invite authors to submit high-quality original research articles and reviews. Researchers and clinicians are encouraged to submit their work including both basic and translational research.

Potential topics include but are not limited to the following:

  • Signaling mechanisms
  • Cytoskeletal regulation
  • Hair cell regeneration
  • Spiral ganglion neuron regeneration
  • Spiral ganglion neuron refinement and retraction
  • Spiral ganglion neuron neurites pruning
  • Application of biomaterials in improving the plasticity of spiral ganglion neuron
  • Ribbon synapse plasticity
  • Noise and drug induced changes in hair cell and spiral ganglion neuron plasticity
  • Genetic aspects regulating plasticity
  • Gene therapy of hearing loss
  • The application of Biomaterials in regeneration
  • Inner ear progenitors and mini organ formation

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3108490
  • - Research Article

The Influence of Cochlear Implant-Based Electric Stimulation on the Electrophysiological Characteristics of Cultured Spiral Ganglion Neurons

Na Shen | Lei Zhou | ... | Shufeng Li
  • Special Issue
  • - Volume 2020
  • - Article ID 8829587
  • - Research Article

Cochlear Implantation in a Patient with a Novel POU3F4 Mutation and Incomplete Partition Type-III Malformation

Xiuhua Chao | Yun Xiao | ... | Lei Xu
  • Special Issue
  • - Volume 2020
  • - Article ID 8860837
  • - Research Article

Targeted Next-Generation Sequencing Identifies Separate Causes of Hearing Loss in One Deaf Family and Variable Clinical Manifestations for the p.R161C Mutation in SOX10

Xiaoyu Yu | Yun Lin | Hao Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 8843485
  • - Review Article

Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy

Baoyi Feng | Chenxi Jin | ... | Hao Wu
  • Special Issue
  • - Volume 2020
  • - Article ID 8831735
  • - Research Article

Atrial Natriuretic Peptide Improves Neurite Outgrowth from Spiral Ganglion Neurons In Vitro through a cGMP-Dependent Manner

Fei Sun | Ke Zhou | ... | Ding-jun Zha
  • Special Issue
  • - Volume 2020
  • - Article ID 9260807
  • - Research Article

A Novel Spontaneous Mutation of the SOX10 Gene Associated with Waardenburg Syndrome Type II

Sen Chen | Yuan Jin | ... | Yu Sun
  • Special Issue
  • - Volume 2020
  • - Article ID 8841522
  • - Research Article

Hearing Phenotypes of Patients with Hearing Loss Homozygous for the GJB2 c.235delc Mutation

Chang Guo | Sha-Sha Huang | ... | Pu Dai
  • Special Issue
  • - Volume 2020
  • - Article ID 8884511
  • - Research Article

The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats

Yusu Ni | Diyan Chen | ... | Huawei Li
  • Special Issue
  • - Volume 2020
  • - Article ID 8829660
  • - Review Article

Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals

Muhammad Waqas | Iram Us-Salam | ... | Shuangba He
  • Special Issue
  • - Volume 2020
  • - Article ID 8872185
  • - Research Article

Compound Heterozygous Mutations in TMC1 and MYO15A Are Associated with Autosomal Recessive Nonsyndromic Hearing Loss in Two Chinese Han Families

Pengcheng Xu | Jun Xu | ... | Tao Yang
Neural Plasticity
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Acceptance rate53%
Submission to final decision58 days
Acceptance to publication37 days
CiteScore5.200
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Impact Factor3.599
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.